Is fishing allowed south of Seacoast Drive now that the nearshore ocean is a Marine Protected Area (MPA)?

Yes, but only certain species and by using specific methods (see below).  The MPA west of the Reserve and south of Seacoast Drive is called the Tijuana River Mouth State Marine Conservation Area (SMCA).

Tijuana River Mouth SMCA

Effective: January 1, 2012

Location:
The SMCA is approximately 1.5 miles wide (west-east, starting at the mean high tide line) and 3miles long (north-south, starting at the south end of Seacoast Drive). View Map.

What am I allowed to fish?
Northern anchovy (Engraulis mordax)
Pacific sardine (Sardinops sagax)
Pacific mackerel (Scomber japonicus)
Jack mackerel (Trachurus symmetricus)

How am I allowed to fish?
Recreational Fishing: by hand-held dip net only.
Commercial Fishing: by round haul net only.

Get a detailed description of the Tijuana River Mouth SMCA boundary and regulations.

CA Dept. of Fish and Wildlife Marine Protected Areas Webpage.

Map of all MPAs in effect on the Southern California Coast.